Purpose : The objective of this study was to reveal the impact of oxaliplatin-induced persistent peripheral neuropathy on the social life of colorectal cancer patients and to review their care and available support services. Patients and Methods : Data was collected from 19 colorectal cancer outpatients treated with oxaliplatin (≥850mg/m² in total) using semi-structured interviews, and the results were analyzed qualitatively and inductively. Results : The results revealed that the impacts of persistent peripheral neuropathy on the social life of colorectal cancer patients could be classified into the following 5 interrelated categories : "fear of the collapse of the foundation of their social life", "dependence and independence in activities of life associated with relationships with others", "fluctuation of self-concept in relation to other people", "deepening of intimacy triggered by numbness", and "numbness as a threat to the value of one's own existence". Conclusions : A hierarchy in the effects of persistent peripheral neuropathy on social life was observed, and the effects of neuropathy, including both mental and spiritual aspects, should therefore be considered in totality. Our study suggested that the comprehensive assessment of patients' persistent peripheral neuropathy is important.