Diffusion-weighted Line-scan Echo-planar Spectroscopic Imaging Technique to Reduce Motion Artifacts in Metabolite Diffusion Imaging

Yoshitaka BITO; Koji HIRATA; Toshihiko EBISU; Yuko KAWAI; Yosuke OTAKE; Satoshi HIRATA; Toru SHIRAI; Yoshihisa SOUTOME; Hisaaki OCHI; Etsuji YAMAMOTO; Masahiro UMEDA; Toshihiro HIGUCHI; Chuzo TANAKA

doi:10.2463/mrms.2014-0024

Major Papers

Diffusion-weighted Line-scan Echo-planar Spectroscopic Imaging Technique to Reduce Motion Artifacts in Metabolite Diffusion Imaging

Yoshitaka BITO , Koji HIRATA, Toshihiko EBISU, Yuko KAWAI, Yosuke OTAKE, Satoshi HIRATA, Toru SHIRAI, Yoshihisa SOUTOME, Hisaaki OCHI, Etsuji YAMAMOTO, Masahiro UMEDA, Toshihiro HIGUCHI, Chuzo TANAKA

Author information

Yoshitaka BITO Corresponding author
Central Research Laboratory, Hitachi, Ltd.
MRI System Division, Hitachi Medical Corporation
Faculty of Engineering, Graduate School of Engineering, Chiba University
Koji HIRATA
Central Research Laboratory, Hitachi, Ltd.
Toshihiko EBISU
Department of Neurosurgery, Nantan General Hospital
Yuko KAWAI
Department of Medical Informatics, Meiji University of Integrative Medicine
Yosuke OTAKE
Central Research Laboratory, Hitachi, Ltd.
Satoshi HIRATA
Central Research Laboratory, Hitachi, Ltd.
Toru SHIRAI
Central Research Laboratory, Hitachi, Ltd.
Yoshihisa SOUTOME
Central Research Laboratory, Hitachi, Ltd.
Hisaaki OCHI
Central Research Laboratory, Hitachi, Ltd.
Etsuji YAMAMOTO
Faculty of Engineering, Graduate School of Engineering, Chiba University
Masahiro UMEDA
Department of Medical Informatics, Meiji University of Integrative Medicine
Toshihiro HIGUCHI
Department of Neurosurgery, Meiji University of Integrative Medicine
Chuzo TANAKA
Department of Neurosurgery, Meiji University of Integrative Medicine

Keywords: diffusion, metabolite, motion artifact, rat, spectroscopic imaging

JOURNAL OPEN ACCESS

2015 Volume 14 Issue 1 Pages 43-50

DOI https://doi.org/10.2463/mrms.2014-0024

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Details

Abstract

Metabolite diffusion is expected to provide more specific microstructural and functional information than water diffusion. However, highly accurate measurement techniques have still not been developed, especially for reducing motion artifacts caused by cardiac pulsation and respiration. We developed a diffusion-weighted line-scan echo-planar spectroscopic imaging (DW-LSEPSI) technique to reduce such motion artifacts in measuring diffusion-weighted images (DWI) of metabolites. Our technique uses line-scan and echo-planar techniques to reduce phase errors induced by such motion during diffusion time. The phase errors are corrected using residual water signals in water suppression for each acquisition and at each spatial pixel specified by combining the line-scan and echo-planar techniques. We apply this technique to a moving phantom and a rat brain in vivo to demonstrate the reduction of motion artifacts in DWI and apparent diffusion coefficient (ADC) maps of metabolites. DW-LSEPSI will be useful for investigating a cellular diffusion environment using metabolites as probes.

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