The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Studies on Experimental Porphyria
Report I. Increased Synthesis of δ-Aminolevulinic Acid in Allylisopropylacetamide-induced Porphyria Rat
Takashi MiyakoshiGoro Kikuchi
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1963 Volume 79 Issue 2 Pages 199-208

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Abstract

A chemical porphyria was induced in rat by feeding allylisopropylacetamide (AIA) and activities in liver mitochondria to synthesize aminoketones were studied.
It was shown that the activity to synthesize δ-aminolevulinic acid (δ-ALA) was high in liver mitochondria from AIA-induced porphyria rat, while it was very low in normal rat. In contrast, both mitochondria from normal and AIA-treated rats produced large amounts of aminoacetone and no activity difference was noticed between normal and porphyria rats. The δ-ALA synthesizing activity of liver mitochondria varied significantly according to the reaction conditions employed; particularly the yield of δ-ALA was increased by omitting ADP or Pi from the reaction system under anaerobic conditions.
Activities of terminal respiration systems in AIA-treated rat were found to be unaffected. δ-ALA was scarcely catabolyzed by liver mitochondrial preparations from either of normal and porphyria rats.
Significance of succinyl-CoA supplying system in controling the activity of δ-ALA synthesis was discussed in relation to chemical porphyria.

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