Morphological Changes of Mitochondria in the Hepatocytes Induced by Administration of a Large Amount of Di (2-ethylhexyl) phthalate (DEHP) to Cynomolgus Monkeys (Macaca fascicularis)

Shigeru Satake; Youhei Tanigawa; Hiroshi Maeda; Yasuhiro Kamimura; Yutaka Chihaya; Hiroaki Miyajima; Masanobu Goryo; Kosuke Okada

doi:10.1293/tox.21.73

Short Communication

Morphological Changes of Mitochondria in the Hepatocytes Induced by Administration of a Large Amount of Di (2-ethylhexyl) phthalate (DEHP) to Cynomolgus Monkeys (Macaca fascicularis)

Shigeru Satake, Youhei Tanigawa, Hiroshi Maeda, Yasuhiro Kamimura, Yutaka Chihaya, Hiroaki Miyajima, Masanobu Goryo, Kosuke Okada

Author information

Keywords: Di (2-ethylhexyl) phthalate (DEHP), cynomolgus monkey, hepatocyte, mitochondria, peroxisome

JOURNAL FREE ACCESS

2008 Volume 21 Issue 1 Pages 73-75

DOI https://doi.org/10.1293/tox.21.73

Details

Abstract

The purpose of this study was to determine the relation between administration of a large amount of Di (2-ethylhexyl) phthalate (DEHP) and peroxisome proliferation in cynomolgus monkey (Macaca fascicularis) hepatocytes. DEHP was administered orally to four cynomolgus monkeys, once daily for 28 days at dose levels of 1,000 and 2,500 mg/kg/day. Enlargement of the mitochondria, and lamellar orientation of the cristae along the major axis of the mitochondria were observed in the hepatocytes; however, we did not observe clear proliferation of peroxisomes.

Corresponding author

Register with J-STAGE for free!