Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract,          Pancreas andSalivary Glands of the Rat and Mouse

Thomas Nolte; Patricia Brander-Weber; Charles Dangler; Ulrich Deschl; Michael R. Elwell; Peter Greaves; Richard Hailey; Michael W. Leach; Arun R. Pandiri; Arlin Rogers; Cynthia C. Shackelford; Andrew Spencer; Takuji Tanaka; Jerrold M. Ward

doi:10.1293/tox.29.1S

Review

Nonproliferative and Proliferative Lesions ofthe Gastrointestinal Tract, Pancreas andSalivary Glands of the Rat and Mouse

Thomas Nolte, Patricia Brander-Weber, Charles Dangler, Ulrich Deschl, Michael R. Elwell, Peter Greaves, Richard Hailey, Michael W. Leach, Arun R. Pandiri, Arlin Rogers, Cynthia C. Shackelford, Andrew Spencer, Takuji Tanaka, Jerrold M. Ward

Author information

Thomas Nolte
Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany
Patricia Brander-Weber
Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4002 Basel, Switzerland
Charles Dangler
Jackson Laboratory, Bar Harbor, Maine 04609, USA
Ulrich Deschl
Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, 88397, Germany
Michael R. Elwell
Covance Laboratories, Inc. 14500 Avion Parkway, Ste 125, Chantilly, Virginia 20151, USA
Peter Greaves
University of Leicester, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Science Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
Richard Hailey
GlaxoSmithKline PO Box 14164 Durham, North Carolina 27709, USA
Michael W. Leach
Pfizer, Inc. One Burtt Road, Andover, MA 01810, USA
Arun R. Pandiri
Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Experimental Pathology Laboratories, Inc. PO Box 12766, Research Triangle Park, North Carolina 27709, USA
Arlin Rogers
Tufts University, Department of Biomedical Sciences, 274 Tremont Street, Massachusetts 02111, USA
Cynthia C. Shackelford
Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
Andrew Spencer
Covance Laboratories Ltd, Alnwick Research Centre, Willowburn Avenue, Alnwick, Northumberland NE66 2JH United Kingdom
Takuji Tanaka
Gifu Municipal Hospital Gifu 500-8285, Japan
Jerrold M. Ward
Global VetPathology, Montgomery Village, MD, USA

Keywords: diagnostic pathology, nomenclature, diagnostic criteria, digestive system or tract, oral cavity, esophagus, stomach, intestine, small intestine, large intestine, salivary glands, pancreas se

JOURNAL FREE ACCESS

2016 Volume 29 Issue 1_Suppl Pages 1S-125S

DOI https://doi.org/10.1293/tox.29.1S

Details

Abstract

The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) project is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature and diagnostic criteria for nonproliferative and proliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature and diagnostic criteria for classifying lesions in the digestive system including the salivary glands and the exocrine pancreas of laboratory rats and mice. Most lesions are illustrated by color photomicrographs. The standardized nomenclature, the diagnostic criteria, and the photomicrographs are also available electronically on the Internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and age related lesions as well as lesions induced by exposure to test items. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature and diagnostic criteria for the digestive system will decrease misunderstandings among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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