Non-proliferative and Proliferative Lesions of the Cardiovascular System of          the Rat and Mouse

Brian R. Berridge; Vasanthi Mowat; Hirofumi Nagai; Abraham Nyska; Yoshimasa Okazaki; Peter J. Clements; Matthias Rinke; Paul W. Snyder; Michael C. Boyle; Monique Y. Wells

doi:10.1293/tox.29.3S-1

Review

Non-proliferative and Proliferative Lesions of the Cardiovascular System of the Rat and Mouse

Brian R. Berridge, Vasanthi Mowat, Hirofumi Nagai, Abraham Nyska, Yoshimasa Okazaki, Peter J. Clements, Matthias Rinke, Paul W. Snyder, Michael C. Boyle, Monique Y. Wells

Author information

Brian R. Berridge
GlaxoSmithKline R&D, Research Triangle Park, NC, USA
Vasanthi Mowat
Huntingdon Life Sciences, Camb, UK
Hirofumi Nagai
Takeda Pharmaceutical Co, Ltd, Fujisawa, Kanagawa, Japan
Abraham Nyska
Consultant in Toxicologic Pathology and Sackler School of Medicine, Tel Aviv University, Timrat, Israel
Yoshimasa Okazaki
AnaPath GmbH, Switzerland
Peter J. Clements
GlaxoSmithKline R&D, Ware, UK
Matthias Rinke
Bayer Pharma AG, Wuppertal, Germany
Paul W. Snyder
EPL, West Lafeyette, IN, USA
Michael C. Boyle
Amgen, Inc., Thousand Oaks, CA, USA
Monique Y. Wells
Toxicology/Pathology Services Inc., Paris, France

Keywords: diagnostic pathology, cardiovascular, CV, nomenclature, circulatory system, vascular system, cardiotoxicity, rodent pathology, vascular injury

JOURNAL FREE ACCESS

2016 Volume 29 Issue 3_Suppl Pages 1S-47S

DOI https://doi.org/10.1293/tox.29.3S-1

Details

Abstract

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Japan (JSTP), Europe (ESTP), Great Britain (BSTP) and North America (STP) to develop an internationally-accepted nomenclature for proliferative and non-proliferative lesions in laboratory animals. The primary purpose of this publication is to provide a standardized nomenclature for characterizing lesions observed in the cardiovascular (CV) system of rats and mice commonly used in drug or chemical safety assessment. The standardized nomenclature presented in this document is also available electronically for society members on the internet (http://goreni.org). Accurate and precise morphologic descriptions of changes in the CV system are important for understanding the mechanisms and pathogenesis of those changes, differentiation of natural and induced injuries and their ultimate functional consequence. Challenges in nomenclature are associated with lesions or pathologic processes that may present as a temporal or pathogenic spectrum or when natural and induced injuries share indistinguishable features. Specific nomenclature recommendations are offered to provide a consistent approach.

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