A class-E power amplifier (PA) with novel dynamic biasing scheme is proposed to enhance power added efficiency (PAE) over a wide power range. A look-up table (LUT) adjusts input power and drain supply voltage simultaneously to keep switch mode condition of a power transistor and to optimize the PAE. Experimental results show that the class-E PA using the proposed scheme with harmonic suppression filter gives the PAE higher than 80% over 8.5 dB range with less than 40 dBc harmonic suppression.