Z-ligustilide Extracted from Radix Angelica Sinensis Decreased Platelet Aggregation Induced by ADP Ex Vivo and Arterio-venous Shunt Thrombosis In Vivo in Rats

Lian ZHANG; Jun-Rong DU; Jin WANG; Dong-Ke YU; Ya-Shu CHEN; Yao HE; Chen-Yuan WANG

doi:10.1248/yakushi.129.855

Regular Articles

Z-ligustilide Extracted from Radix Angelica Sinensis Decreased Platelet Aggregation Induced by ADP Ex Vivo and Arterio-venous Shunt Thrombosis In Vivo in Rats

Lian ZHANG, Jun-Rong DU, Jin WANG, Dong-Ke YU, Ya-Shu CHEN, Yao HE, Chen-Yuan WANG

Author information

Lian ZHANG
Department of Pharmacology and Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education, West China School of Pharmacy, Sichuan University
Jun-Rong DU
Department of Pharmacology and Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education, West China School of Pharmacy, Sichuan University
Jin WANG
Department of Pharmacology and Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education, West China School of Pharmacy, Sichuan University
Dong-Ke YU
Department of Pharmacology and Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education, West China School of Pharmacy, Sichuan University
Ya-Shu CHEN
Department of Pharmacology and Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education, West China School of Pharmacy, Sichuan University
Yao HE
Department of Pharmacology and Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education, West China School of Pharmacy, Sichuan University
Chen-Yuan WANG
Department of Pharmacology and Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of Education, West China School of Pharmacy, Sichuan University

Keywords: Radix Angelica sinensis, Z-ligustilide, thrombosis, platelet aggregation, coagulation time

JOURNAL FREE ACCESS

2009 Volume 129 Issue 7 Pages 855-859

DOI https://doi.org/10.1248/yakushi.129.855

J-STAGE : yakushi 134 3 pp.455-455

Details

Abstract

Antithrombotic therapy has become an important goal for the treatment of ischemic disorders such as cerebral ischemia. Our recent studies found that Z-ligustilide (LIG), a characterized 3-n-alkylphthalide constituent of Radix Angelica sinensis essential oil, exerted significant neuroprotection against cerebral ischemic damage in several animal models. The present study evaluated the antithrombotic activity of LIG and its effect on platelet aggregation and coagulation time. LIG (10 or 40 mg/kg) was intragastrically administered to rats once daily for 3 days. Our results showed that LIG significantly and dose-dependently reduced arterial thrombus weight in an arteriovenous shunt thrombosis in rats and platelet aggregation induced by adenosine diphosphate in rats ex vivo. Meanwhile, LIG at 10 or 40 mg/kg had no significant effect on coagulation time, including activated partial thromboplastin time and prothrombin time, in rats ex vivo. The present study demonstrated for the first time that LIG may exert efficient antithrombotic activity through inhibition of platelet aggregation, without effecting coagulation time of peripheral blood. These data, together with the previously reported neuroprotective effects of LIG on cerebral ischemia, suggest that the antithrombotic activity of LIG may contribute to its potential for the treatment of ischemic diseases, including ischemic stroke.

Corresponding author

Register with J-STAGE for free!