In Vitro Activities of 11 Antimicrobial Agents against Macrolide-Resistant Mycoplasma pneumoniae Isolates from Pediatric Patients: Results from a Multicenter Surveillance Study

Hiroto Akaike; Naoyuki Miyashita; Mika Kubo; Yasuhiro Kawai; Takaaki Tanaka; Satoko Ogita; Kozo Kawasaki; Takashi Nakano; Kihei Terada; Kazunobu Ouchi; the Atypical Pathogen Study Group

doi:10.7883/yoken.65.535

Short Communication

In Vitro Activities of 11 Antimicrobial Agents against Macrolide-Resistant Mycoplasma pneumoniae Isolates from Pediatric Patients: Results from a Multicenter Surveillance Study

Hiroto Akaike, Naoyuki Miyashita, Mika Kubo, Yasuhiro Kawai, Takaaki Tanaka, Satoko Ogita, Kozo Kawasaki, Takashi Nakano, Kihei Terada, Kazunobu Ouchi, the Atypical Pathogen Study Group

Author information

Hiroto Akaike
Department of Pediatrics, Kawasaki Medical School
Naoyuki Miyashita
Department of Internal Medicine 1, Kawasaki Medical School
Mika Kubo
Department of Pediatrics, Kawasaki Medical School
Yasuhiro Kawai
Department of Pediatrics, Kawasaki Medical School
Takaaki Tanaka
Department of Pediatrics, Kawasaki Medical School
Satoko Ogita
Department of Pediatrics, Kawasaki Medical School
Kozo Kawasaki
Department of Pediatrics, Kawasaki Medical School
Takashi Nakano
Department of Pediatrics, Kawasaki Medical School
Kihei Terada
Department of Pediatrics, Kawasaki Medical School
Kazunobu Ouchi
Department of Pediatrics, Kawasaki Medical School
the Atypical Pathogen Study Group

JOURNAL FREE ACCESS

2012 Volume 65 Issue 6 Pages 535-538

DOI https://doi.org/10.7883/yoken.65.535

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Abstract

Macrolide-resistant Mycoplasma pneumoniae is emerging in several countries, and it is mainly observed in children. To our knowledge, we conducted the first multicenter prospective epidemiological study of macrolide-resistant M. pneumoniae in order to investigate regional differences in the susceptibility of macrolide-resistant M. pneumoniae to antibacterial agents. The in vitro activities of 11 antimicrobial agents against macrolide-resistant M. pneumoniae isolates from 5 different areas of Japan were investigated. Among 190 M. pneumoniae isolates from pediatric patients, 124 (65.2%) isolates showed macrolide resistance and possessed an A2063G transition in domain V of the 23S rRNA. These isolates showed high resistance to erythromycin, clarithromycin, and azithromycin with minimum inhibitory concentrations (MICs) ≥16 μg/ml. Conversely, quinolones such as garenoxacin, moxifloxacin, tosufloxacin, and levofloxacin exhibited potent antimycoplasmal activity. No regional differences were observed with respect to the MICs among the 5 areas in Japan.

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