Annals of Cancer Research and Therapy
Online ISSN : 1880-5469
Print ISSN : 1344-6835
ISSN-L : 1344-6835
Original Articles
BRM cocktail treatment using PSK and OK432 significantly up-regulates the migration activity in human dendritic cells without losing effective CTL induction
Mika HoshinoHiroyuki SuzukiSeigo KashimuraNorio KanzakiHiroshi YaginumaTakeo HasegawaAtsushi YonechiJun OhsugiMitsunori HiguchiYutaka ShioKazuya IseMitsukazu Gotoh
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2011 Volume 19 Issue 1 Pages 1-8

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Abstract

One of the major factors for successful DCs immunotherapy is thought to be the maintenance of the migratory activity of matured DCs. We evaluated the effectiveness of PSK on OK432-activated DCs, in terms of maturation, migration and induction of CTLs. When DCs were treated with both OK432 and PSK, migration ability of the DCs were significantly high as compared to OK432 alone preserving the beneficial effect of OK432 treatment. BRM cocktail treatment with OK432 and PSK induced high level of migration activity in activated DCs, suggesting a potential protocol for more effective DCs immunotherapy for cancer.

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© 2011 by The Japanese Society of Strategies for Cancer Research and Therapy
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