Abstract
Whether the hereditary cancer patients had survival advantage is a question that is still open for discussion. We suppose that the genes of cancer patients who have family histories are more diverse or polymorphic, or they are potentially more mutational than those without family history of cancer; consequently, these patients may have relatively good outcomes even if they are suffering from cancer.
A consecutive series of 2880 Japanese cancer patients with a median follow-up of 2942 days was evaluated to know their outcomes and their family histories.
Cancer patients with a positive family history have a five-fold increased risk of benign disease patients. Outcomes of cancer patients whose near relatives were suffering from cancer had better outcomes in especially females in first relatives. Outcomes of cancer patients whose parents were suffering from cancer had better than the other groups.
Our results establish the correlation between cancer family history and outcome, resulting good outcomes following good treatment for cancer and that potentially important genetic information that key genes which correlate a long-life may be located on X chromosome.
