1981 年 14 巻 6 号 p. 581-587
Immunohistochemical localization of dipeptidyl aminopeptidase (DAP) IV in the rat endocrine organs was studied using the unlabeled antibody method. Fresh frozen, chloroform-acetone treated sections of the endocrine organs (pineal, pituitary, thyroid, parathyroid, adrenal gland and pancreas) were investigated for the present study.
A fairly intense immunoreaction of DAP IV was detected in the capillary endothelium of the thyroid gland and adrenal cortex. The capillary endothelium of the pineal, pituitary, parathyroid gland and pancreatic islets showed faint immunoreaction. No immunoreaction could be seen in the parenchymal cells of these endocrine organs except for the follicular epithelial cells of the thyroid gland.
These results indicated that DAP IV in the endocrine organs was restricted to the capillary endothelium, and showed organ-dependent differences. Especially, it seemed that DAP IV in the capillary endothelium might be of importance in the thyroid and adrenal glands.