POSTNATAL DEVELOPMENT OF ACETYLCHOLINESTERASE IN SELECTED RAT BRAIN REGIONS

I. BEHAVIOUR OF ITS MULTIPLE FORMS IN THE MEDIAL SEPTAL NUCLEUS AND HIPPOCAMPUS

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The behaviour of the multiple forms of soluble and Triton-solubilized acetylcholinesterase was investigated using microgel gradient electrophoresis at selected days of postnatal development. Three to four anodically migrating forms designated with A (fast migrating) to D (slow migrating) could be separated in the adult rat brain. The comparison of both enzyme fractions revealed differences in regard to the most active form at early stages of development and the maturation of the pattern of multiple forms of acetylcholinesterase.