HISTOCHEMICAL ANALYSIS BY LECTIN IN COMPARISON WITH IMMUNOHISTOCHEMICAL PROLACTIN STAINING OF PRENEOPLASTIC AND NEOPLASTIC MAMMARY GLANDS IN FOUR STRAINS OF MICE

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Preneoplastic mammary hyperplastic alveolar nodules (HAN) and mammary tumors in four strains of mice (SHN/Mei, SLN/Mei, C3H/HeMei and GR/AMei) with different mammary tumor potentials were investigated histochemically by lectin from peanuts in comparison with the pattern of immunohistochemical prolactin (PRL) staining. Most HAN exhibited positive PNA and PRL staining in all strains. Meanwhile, the percentage of mammary tumors showing positive staining of all cells with PNA was lower in C3H/HeMei and higher in SHN/Mei than in the other strains. Little difference was found between strains in percentage of mammary tumors containing cells with positively immunoreactive PRL, although the tumors bearing PRL-positive cells always showed PNA-positive staining.