ULTRASTRUCTURAL EVIDENCE FOR THE BIOGENESIS OF D-AMINO ACID OXIDASE-CONTAINING PEROXISOMES IN ‘NORMAL’ FETAL MOUSE LIVER IN MUSCULAR DYSGENESIS

Abstract

D-amino acid oxidase (DAAO) cytochemistry was undertaken in the ‘normal’ liver of fetal mice obtained from mothers carrier of muscular dysgenesis. Developing and differentiating hepatocytes revealed that DAAO is released from mitochondria and immediately enveloped by smooth membrane in the cytoplasm to form DAAO-containing peroxisomes. DAAO synthesized in the cytosol may be relocated in mitochondria before being released back into cytosol.