Occasionally, district heating and cooling center has been built in general buildings. In these case, large caliber water piping system is installed at pipe-shaft near rooms in the buildings, and structure-borne noise generated by pipe vibration propagated from pumps etc. influence for the room's environment. So, it is necessary lo study on the prediction and control of these vibration and structure-borne noise. In order to know the source and propagation characteristics of noise and vibration at large caliber water piping system, the basic measurements on noise and vibration were carried out in the building in where large caliber water piping system is installed. And the investigations on noise and vibration propagation were carried out using real scale model of rooms and pipe. From these results, the reduction system of structure-borne noise generated by large caliber water pipe to be installed at pipe-shaft was developed and applicated at the hotel in where district heating and cooling center was built, also the noise reduction effect of the system was measured. In this paper, these results are described.