The results of the field measurement on the heat load and indoor environment of a large air-conditioned factory space in comparison with the simulation results are described together with the results of the questionnaire to the workers. It was found that the air conditioning effectively cooled the work space in summer and that the cold air was spread from the west part to the heated working zone of east and central parts in winter. The vertical temperature gradient obviously appeared in the space above 3m from the floor in summer, while the space above was heated to be at higher uniform temperature in winter. Although a greater amount of heat load was resulted with simulation than measurement, it could be judged that the simulation expressed the heat load of this factory quite well except for the start up period both in summer and winter. The results of CFD analysis turned out quite similar to the measured results with regard to the distribution patterns of air temperature and air flow. The workers of the factory were slightly satisfied with the indoor environment in summer and winter as found from the questionnaire and seemed to be accustomed to rather low temperature in winter.