The purpose of this study was to develop a prediction tool for designing and building houses with low volatile organic compounds (VOCs) to prevent people diagnose sick building syndrome. First, 116 VOCs were analyzed in detail from 124 indoor air samples collected at 29 rooms in 8 houses for over 5 years. Next, multivariate analysis was conducted to find the influencing factors and contribution on the VOC emission. As the results, it became clear that flooring materials, construction method and time after finishing construction were the major factors. Finally, a prediction tool of VOC level in indoor air was designed.