The present study investigates the seismic performance of twelve-story RC buildings focusing on the structural effects of flat walls which are commonly neglected in design practice. Two-span moment-resisting frame was numerically modeled considering three analytical cases: Case 0 of beam-column subassembly, Case 1 with conventional flat walls, and Case 2 with damage control flat walls which were proposed in the authors’ previous study. Comparing the seismic performance of the three models based on the analytical results, the damage control flat walls were found to contribute to enhance both the serviceability and safety limits of the subassembly.