Masonry walls are widely used as infill in RC buildings even in the countries with high seismicity and affect the seismic performance of buildings. Due to the vulnerability of masonry infill walls to earthquakes, out-of-plane collapse should be considered when their effects on the seismic performance of buildings are discussed. Hence, this study was performed to experimentally investigate the out-of-plane behavior/performance of a typical brick masonry infill wall in Bangladesh and to propose a simplified analytical model to estimate the out-of-plane resistance. Findings from this study will contribute to the performance evaluation of RC buildings with masonry infill walls.