Flow-Injection Electrogenerated Chemiluminescence Determination of Isoniazid Using Luminol

Abstract

Based on a new electrogenerated chemiluminescence (ECL) analytical idea, this paper explains a sensitive and selective flow-injection ECL method using luminol for the determination of isoniazid, based on the sensitizing effect of isoniazid for the weak ECL emission of electrochemically oxidized luminol. Under the optimum experimental conditions, the relative ECL intensity was linear with isoniazid concentration in the range of 4.0 × 10^-8 mol/L to 8.0 × 10^-6 mol/L and with a detecting limit of 2.8 × 10^-8 mol/L.