Sulfadiazine-Potentiometric Sensors for Flow and Batch Determinations of Sulfadiazine in Drugs and Biological Fluids

Abstract

New PVC membrane electrodes for the determination of sulfadiazine (SDZ) are presented. The electrodes are fabricated with conventional and tubular configurations with a graphite-based electrical contact, and no internal reference solution. The selective membranes consist of bis(triphenylphosphoranilidene)ammonium·SDZ (electrode A), tetraoctylammonium bromide (electrode B), or iron(II)-phthalocyanine (FePC) (electrode C) electroactive materials dispersed in a PVC matrix of o-nitrophenyl octyl ether (o-NPOE) plasticizer. The sensors A, B, and C displayed linear responses over the concentration ranges 1.0 × 10^-2 - 1.0 × 10^-5, 1.0 × 10^-2 - 7.5 × 10^-6, and 3.2 × 10^-2 - 7.0 × 10^-6 mol l^-1 (detection limits of 1.09, 2.04 and 0.87 µg ml^-1) with anionic slopes of -57.3 ± 0.1, -46.7 ± 0.5, and -65.1 ± 0.2 mV decade^-1, respectively. No effect from pH was observed within 4.0 - 5.5, 4.8 - 10, and 4.5 - 8, respectively, and good selectivity was found. The sensors were applied to the analysis of pharmaceuticals and biological fluids in steady state and in flow conditions.