J-STAGE Home  >  Publications - Top  > Bibliographic Information

Analytical Sciences
Vol. 26 (2010) No. 8 P 891-896



Original Papers

The simultaneous determination of albendazole (ABZ) and praziquantel (PZQ) was performed by different mathematical approaches: second derivative spectrophotometry (SDS), classical least squares, regression of partial least squares and principal components regression based on spectral data of drugs dissolved in methanol-hydrochloric acid solution. The detection limits for multivariate calibrations were determined by creating a surrogate variable signal. SDS presented the best analytical features. The recoveries of ABZ and PZQ from the synthetic samples were near to 100 ± 5%. The methods were applied in veterinary pharmaceutical formulation whose mass ratio ABZ:PZQ is 10:1; the results obtained were according to nominal content.

Copyright © 2010 by The Japan Society for Analytical Chemistry

Article Tools

Share this Article