Differential Pulse Anodic Voltammetric Determination of Tiapride Hydrochloride in Pharmaceutical Preparation and Human Urine Using Carbon Paste Electrodes

Abstract

The anodic voltammetric behavior of tiapride hydrochloride (TiapCl) was studied at carbon paste electrodes in 0.04 M Britton–Robinson buffer pH 7.0 using cyclic and differential pulse voltammetric techniques. The oxidation of TiapCl is an irreversible diffusion-controlled process. A differential pulse anodic voltammetric procedure has been developed for determination of the drug over the concentration range 0.36 – 19.35 μg/ml with detection and quantification limits of 0.12 and 0.40 μg/ml, respectively. The proposed method was successfully applied for the determination of the drug in commercial tablets and in spiked human urine samples.