Analytical Sciences: X-ray Structure Analysis Online
Online ISSN : 1348-2238
ISSN-L : 1348-2238
October - December (2003)
Crystal Structure of 5′-Hydroxythalidomide In Vivo Metabolite of Thalidomide in Humans
Mitsunobu DOIYoshio IJIRIMasao AKAGIMiharu UENISHIHidehito URATA
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2003 Volume 19 Pages x51-x52

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Abstract

A metabolite of thalidomide, 5′-hydroxythalidomide (1), was crystallized from acetonitrile solution. The angle between the least-square planes of the glutarimide ring and the phthalimide plane was 83.52(6)°. This conformation was similar to that of thalidomide and the thalidomide structure was not significantly affected by the hydroxylation of the glutarimide ring.

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© 2003 by The Japan Society for Analytical Chemistry
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