2021 Volume 58 Issue 3 Pages 241-245
Cisplatin is known to have side effects such as nausea and vomiting and may cause a stress response. In this study, we investigated the effects of peripheral administration of cisplatin on the hypothalamo-pituitary-adrenal (HPA) axis and autonomic nervous system, using arginine vasopressin (AVP)-eGFP transgenic rats. Cisplatin administration caused significant increases of AVP-eGFP fluorescent intensities and the number of AVP-eGFP expressing cells with FosB-ir in the parvocellular division of the paraventricular nucleus (pPVN). In addition, AVP, eGFP and CRH mRNA in the pPVN were also increased significantly after cisplatin administration. Although increased plasma concentrations of catecholamine could not be captured, corticosterone in plasma were increased significantly after cisplatin administration. These results suggest that peripheral administration of cisplatin may activate the HPA axis via hypothalamic AVP and CRH.
