Natural products-inspired chemical biology toward development of new antibiotics

Abstract

Infectious diseases caused by antibiotic-resistant bacteria has greatly increased and brought a recent public health crisis worldwide. Therefore, it is requisite to develop new antibiotics with a novel pharmacophore or molecular target. In this review, chemistry and antimicrobial properties of new microbial metabolites, tumescenamide C, chlorocatechelins, and saccharothriolides, as pharmaceutical leads produced by actinomycetes such as Streptomyes sp. and the rare actinomycete Saccharothrix sp. are summarized. In addition, precursor-directed in situ synthesis (PDSS) to obtain new derivatives of microbial metabolites in one pot is also described.