SYNTHESIS OF 6-AMINOPENICILLANIC ACID DERIVATIVES. IV 6-(SYDNONE-3-ACETAMIDO)PENICILLANATES AND 7-(SYDNONE-3-ACETAMIDO)CEPHALOSPORANATES

TAKAYUKI NAITO; SUSUMU NAKAGAWA; KIYOSHI TAKAHASHI; KEI-ICHI FUJISAWA; HIROSHI KAWAGUCHI

doi:10.7164/antibiotics.21.300

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

SYNTHESIS OF 6-AMINOPENICILLANIC ACID DERIVATIVES. IV

6-(SYDNONE-3-ACETAMIDO)PENICILLANATES AND 7-(SYDNONE-3-ACETAMIDO)CEPHALOSPORANATES

TAKAYUKI NAITO, SUSUMU NAKAGAWA, KIYOSHI TAKAHASHI, KEI-ICHI FUJISAWA, HIROSHI KAWAGUCHI

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1968 Volume 21 Issue 4 Pages 300-305

DOI https://doi.org/10.7164/antibiotics.21.300

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Abstract

6-(Sydnone-3-acetamido) penicillanates and 7-(sydnone-3-acetamido) cepha losporanates were prepared by N-acylation of 6-APA or 7-ACA with sydnone 3-acetyl chloride. The new series of semi-synthetic antibiotics were compared with ampicillin and cephalothin. Sydonylmethylpenicillin (BBP-425) and sydnonylmethylcephalosporin (BBP-428) were active against gram-positive and gram-negative microbes both in vitro and in vivo.

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