STUDIES ON MICROBIAL DEGRADATION OF CEPHALOSPORIN C DERIVATIVES. II

ON THE DEGRADATION OF SEVERAL DERIVATIVES AND THE ACTIVITIES OF SOME STRAINS ISOLATED FROM PATIENTS

Abstract

Several cephalosporin derivatives were classified into three groups based on their degradation by bacteria. Different properties of m-Br-PACA and α-Ph-POCA with respect to microbial degradations were also found with other clinically isolated strains of Staph. aureus and E. coli. The antibacterial activity of cephalosporin derivatives is related to degradation by Staph. aureus No. 33, but not that by E. coli No. 11.