A NEW ANTIBIOTIC, HONDAMYCIN. II

TAXONOMY OF PRODUCING ORGANISM, PRODUCTION AND BIOLOGICAL PROPERTIES OF HONDAMYCIN

Abstract

A strain, Streptomyces sp. No. 771, was isolated from a soil sample collected in Chiba Prefecture. The strain produced a new antibiotic which was isolated as colorless hexagonal crystals and named hondamycin. Hondamycin is mainly active against phytopathogenic fungi and Trichophyton, but is not active against any bacteria. The LD₅₀ was 1.43mg/kg by intraperitoneal route and greater than 500mg/kg orally. This strain was recognized to be a variety of Streptomyces griseochromogenes and named Streptomyces griseochromogenes var. albicus.