STUDIES ON CIRRAMYCIN A1. IV DERIVATIVES OF CIRRAMYCIN A<sub>1</sub>

HIROSHI TSUKIURA; MASATAKA KONISHI; MIEKO SATA; KEI-ICHI FUJISAWA; TOMOO OHMORI; TOSHIO HOSHIYA; HIROSHI KAWAGUCHI

doi:10.7164/antibiotics.22.100

STUDIES ON CIRRAMYCIN A₁. IV

DERIVATIVES OF CIRRAMYCIN A₁

HIROSHI TSUKIURA, MASATAKA KONISHI, MIEKO SATA, KEI-ICHI FUJISAWA, TOMOO OHMORI, TOSHIO HOSHIYA, HIROSHI KAWAGUCHI

著者情報

ジャーナルフリー

1969 年 22 巻 3 号 p. 100-105

DOI https://doi.org/10.7164/antibiotics.22.100

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抄録

A variety of cirramycin derivatives has been prepared by modifying the hydroxyl groups, aldehyde function, dimethylamino group of mycaminose or the conjugated carbonyl system of the cirramycin A₁ molecule. Among the derivatives evaluated, disuccinylcirramycin A₁ (III) was found to possess some improved biological properties with respect to oral absorption, local tissue irritability as well as general toxicity.

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