AZIRINOMYCIN. I

MICROBIAL PRODUCTION AND BIOLOGICAL CHARACTERISTICS

Abstract

A new antibiotic, azirinomycin, has been discovered in the culturejbroth of newly isolated strains of actinomycetes. It was produced by submerged culture in shaken Erlenmeyer flasks in complex organic media. Azirinomycin and its methyl ester were found to exhibit broad spectrum antibiotic activity, in vitro, against both Gram-positive and Gram-negative bacteria. Both azirinomycin and its methyl ester were toxic to mice, and failed to protect them against lethal bacterial infections.