STUDIES ON NEW ANTIBIOTIC LIVIDOMYCINS

II. ISOLATION AND CHARACTERIZATION OF LIVIDOMYCINS A, B AND OTHER AMINOGLYCOSIDIC ANTIBIOTICS PRODUCED BY STREPTOMYCES LIVIDUS

Abstract

Aminoglycosidic antibiotics have been isolated from Streptomyces lividus nov. sp., and purified by ion-exchange column chromatography. Two of them containing 2-amino-2, 3-dideoxy-D-glucose were named lividomycins A and B. One further compound, also confirmed to be a new memberof the paromomycin group was provisionally designated as antibiotic No. 2230-C. The fourth compound which was designated as No. 2230-D was identified as paromomycin I. Lividomycins A, B and No. 2230-C were active against Gram-positive and Gram-negative bacteria including Mycobacterium sp.