TOLYPOMYCIN, A NEW ANTIBIOTIC. III

ISOLATION AND CHARACTERIZATION OF TOLYPOMYCIN Y

Abstract

Tolypomycin Y, C₄₃H₅₄N₂O₁₄, is a new ansamycin antibiotic produced by Streptomyces tolypophorus. It is a lipophylic neutral substance that crystallizes as yellow needles and has λ^EtOH_max 232, 290, 337, 370-430 (shoulder) mμ and [α]²²_D+326° (in EtOH). Tolypomycin Y shows strong in vitro and in vivo antimicrobial activities against Gram-positive bacteria and a low acute toxicity.