The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
THE INDUCTION OF AN ATP-ENERGIZED MITOCHONDRIAL VOLUME CHANGE BY THE COMBINATION OF THE -S-S-COMPOUND GLIOTOXIN WITH EITHER A RESPIRATORY INHIBITOR OR AN UNCOUPLING AGENT
HERBERT I. HADLERMITCHELL R. HADLERBARBARA G. DANIEL
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1973 Volume 26 Issue 1 Pages 30-35

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Abstract

When gliotoxin, an antibiotic, an antitumor agent and an antiviral agent, was combined with either a respiratory inhibitor or an uncoupling agent, an ATP-energized mitochondrial volume change was induced. The effect was attributed to the reaction of an exposed nucleophilic mitochondrial thiol group with the electrophilic -S-S- group in gliotoxin. While this type of interaction may be applied to assist the antitumor and toxic activities of gliotoxin it is difficult to relate the reported interaction to the antiviral activity of gliotoxin except as a model reaction.

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