The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
OTOTOXICITY STUDIES WITH BB-K8, A NEW SEMISYNTHETIC AMINOGLYCOSIDE ANTIBIOTIC
J. G. REIFFENSTEINS. W. HOLMESG. H. HOTTENDORFM. E. BIERWAGEN
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1973 Volume 26 Issue 2 Pages 94-100

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Abstract

BB-K 8, a new semisynthetic aminoglycosidic antibiotic, was evaluated for ototoxicity, nephrotoxicity and neuromuscular blocking activity in the cat. As a reference, kanamycin was tested by the same experimental methods. Employing equivalent doses in terms of the free base and 7 days of intraperitoneal treatment, BB-K 8 and kanamycin were found to be similarly ototoxic and nephrotoxic. Acutely, both compounds also demonstrated a similar neuromuscular blocking activity after large intravenous doses.

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© Japan Antibiotics Research Association
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