CHILAPHYLIN, A NEW ANTIBIOTIC PRODUCED BY STREPTOMYCES MELANOSPOROFACIENS STRAIN CHILEA

Abstract

A soil isolate, designated Streptomyces melanosporofaciens strain Chilea, differentiated from the type strain Streptomyces melanosporofaciens ISP 5318 mainly by its compact spirals, positive sucrose utilization and different pattern of antibiotics, was found to produce a new antibiotic proposed as chilaphylin. Chilaphylin is a neutral, probably aliphatic compound, active in vitro against Gram-positive bacteria including Mycobacterium, and different from melanosporin and elaiophylin, the main antibiotics produced by the type strain ISP 5318.