Abstract
A new group of macrolide antibiotics was obtained from the fermentation broth of Streptomyces hygroscopicus No. B-5050. Isolation of six components, maridomycins I, II, III, IV, V and VI, has been accomplished by silica gel adsorption or partition chromatography. They show only end absorption in UV-spectra and are classified as new macrolide antibiotics from their physicochemical, chemical and biological properties.