ANTIMETABOLITES PRODUCED BY MICROORGANISMS. VII¹⁾

L-(N⁵-PHOSPHONO)METHIONINE-S-SULFOXIMINYL-L-ALANYL-L-ALANINE

Abstract

A new antibiotic was isolated from the fermentation broth of an unclassified species of Streptomyces. The antibiotic activity against Serratia sp. and Bacillus subtilis, grown in a chemically defined minimal medium, was reversed by the addition of L-glutamine to the medium. Physical chemical characterization of the antibiotic and of the chemical and enzymatic degradation products revealed the structure to be L-(N⁵-phosphono)methionine-S-sulfoximinyl-L-alanyl-L-alanine.