AMINOGLYCOSIDE ANTIBIOTICS. IV

BU-1709 E₁ AND E₂, NEW AMINOGLYCOSIDE ANTIBIOTICS RELATED TO THE BUTIROSINS

Abstract

In a previous paper¹⁾ we reported that Bacillus circulans, strain No. YQW-B6, produced a complex of aminoglycoside antibiotics designated Bu-1709, of which the two major components, A₁ and A₂, were identified as butirosins A and B²⁾. Two additional components, E₁ and E₂, have now been isolated and characterized. They have antibacterial spectra similar to the butirosins but with substantially less intrinsic activity. Bu-1709 E₁ and E₂ contain the paromamine moiety in place of the neamine moiety of the butirosins.