INTERACTIONS OF DNA WITH ZORBAMYCIN, PHLEOMYCIN AND BLEOMYCIN; ULTRAVIOLET ABSORPTION AND CIRCULAR DICHROISM MEASUREMENTS

Abstract

Mixtures of DNA with the three antibiotics zorbamycin, phleomycin or bleomycin were analyzed by UV and circular dichroism measurements. The results indicate that a physical interaction between isolated DNA and each of the three antibiotics occurs and that these antibiotics definitely bind to DNA.