A9145, A NEW ADENINE-CONTAINING ANTIFUNGAL ANTIBIOTIC

I. DISCOVERY AND ISOLATION

Abstract

A9145 is a new water-soluble antifungal antibiotic produced by a strain of Streptomyces griseolus (NRRL 3739). This basic antibiotic has an apparent molecular weight of about 510, contains adenine and a possible sugar moiety, and forms crystalline organic and inorganic salts. A9145 is active against Candida species, Saccharomyces pastorianus, plant disease fungi, and Trypanosoma species. It has an LD₅₀ (subcutaneous) of 185 mg/kg in mice.