Abstract
Macarbomycin is an antibiotic produced by Streptomyces phaeochromogenes, inhibitory mainly against Gram-positive bacteria including drug-resistant strains and with low toxicity. It is readily soluble in water and relatively stable over a wide pH range. Its antibacterial activity is markedly reduced by serum albumin. The antibiotic shows a moderate curative activity to staphylococcal infection in mice. When intravenously injected into mice, macarbomycin is excreted slowly. It is apparently not absorbed as such from the alimentary tract. By long-term oral administrations to baby and juvenile monkeys, macarbomycin promoted growth with no signs of toxicity.
