J-STAGE Home  >  Publications - Top  > Bibliographic Information

The Journal of Antibiotics
Vol. 28 (1975) No. 10 P 727-732



Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183-185°C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin.

Copyright © Japan Antibiotics Research Association

Article Tools

Share this Article