The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STIMULATORY EFFECT OF AMPHOTERICIN B METHYL ESTER ON THE GROWTH OF L-M AND VERO CELLS
PAUL B. FISHERNEIL I. GOLDSTEINDANIEL P. BONNERWITOLD MECHLINSKIVERNON BRYSONCARL P. SCHAFFNER
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JOURNAL FREE ACCESS

1975 Volume 28 Issue 11 Pages 896-902

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Abstract

The chemically modified polyene macrolide antibiotic, amphotericin B methyl ester (AME), exhibited a concentration-dependent growth stimulatory effect on established lines of mouse (L-M) and monkey (Vero) cells. Stimulation was indicated by increases in growth rate, and in the enhanced synthesis of DNA and RNA. In contrast, the parental antibiotic amphotericin B and the desoxycholate complex of amphotericin B, Fungizone R, did not elicit a similar proliferative response in L-M or Vero cells. AME was not growth-promoting toward low passage strains of mouse(PMK 6) and monkey cells (GMK 8).

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