GRISORIXIN, AN IONOPHOROUS ANTIBIOTIC OF THE NIGERICIN GROUP

II. CHEMICAL AND STRUCTURAL STUDY OF GRISORIXIN AND SOME DERIVATIVES

Abstract

Grisorixin, a polycyclic polyether antibiotic of the nigericin group, showed ionophorous properties. The conformations of crystallized grisorixin and its metallic salts are very similar and are compared in this paper. The physico-chemical properties of the salts are described. The chemical oxidation of grisorixin methyl ester allowed us to isolate several oxidation products whose structures are described.