EM49, A NEW PEPTIDE ANTIBIOTIC&

IV. THE STRUCTURE OF EM49

Abstract

EM49 is a family of similar peptide antibiotics, each an octapeptide acylated with a &-hydroxy fatty acid. This paper describes the determination of the structure of the fatty acyl residue, the selective removal of this residue from the peptide portion of the molecule, and the sequential analysis of the peptide by the EDMAN method. The structure of EM49, 1, is derived by this degradation.