SORBISTIN, A NEW AMINOGLYCOSIDE ANTIBIOTIC COMPLEX OF BACTERIAL ORIGIN

I. PRODUCTION, ISOLATION AND PROPERTIES

Abstract

A strain of a new Pseudomonas species produced the aminoglycoside antibiotic complex, sorbistin, which was separated by ion-exchange chromatography into three bio-active components A₁, A₂ and B, and two bio-inactive components C and D. Sorbistins A₁, A₂ and B showed moderate intrinsic activity against a wide range of bacterial species and inhibited most of the aminoglycoside-resistant organisms. Sorbistin A₁ exhibited the highest activity among the three bio-active components. Sorbistins showed low order of acute toxicity in mice.