The Journal of Antibiotics
Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820
STUDIES ON JUVENIMICIN, A NEW ANTIBIOTIC. I
TAXONOMY, FERMENTATION AND ANTIMICROBIAL PROPERTIES
KAZUNORI HATANOEIJI HIGASHIDEMOTOO SHIBATA
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1976 Volume 29 Issue 11 Pages 1163-1170

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Abstract

An actinomycete, strain No. T-1124, was found to produce new macrolide antibiotics, juvenimicins. Based on the results of taxonomic studies, the strain was considered to be a new variety of Micromonospora chalcea and the name Micromonospora chalcea var. izumensis is proposed. This strain also produced everninomicin. The production of juvenimicins was stimulated by addition of ferrous sulfate and magnesium sulfate in the fermentation medium. Among juvenimicins, juvenimicin A3 exhibited the most potent antimicrobial activities against gram-positive bacteria and furthermore was active against gram-negative bacteria.

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© Japan Antibiotics Research Association
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