MICROBIAL TRANSFORMATION OF ANTIBIOTICS

II. ADDITIONAL TRANSFORMATION PRODUCTS OF MARIDOMYCIN III

Abstract

Streptomyces sp. strain No. K-245 was found to transform maridomycin III into four derivatives (A₁, A₂, A₃ and A₄) in addition to the transformation products reported previously. Isolation of the main product A₁ was carried out by column chromatography on silica gel developed with CHCl₃-MeOH (19:1). From the partial investigation of the structure of A₁ it proved to have a C 18-aldehyde group and C 4"-propionyl group but no antimicrobial activity. The relationships between A group's derivatives and known derivatives of maridomycin III are also discussed.